25 year spotlight: Professor John Simes

John Simes_photo

“It is a privilege to work with such a dedicated group of clinicians and researchers on clinical trials in gastro-intestinal cancer. The skills of investigators and teams working together on high-quality trials, addressing important questions in GI cancer, is what ultimately makes a difference to the quality of health care. It is also particularly pleasing to have the support of an ever-expanding and engaged group of patients, carers and consumers in this effort. Together, with the AGITG and the NHMRC Clinical Trials Centre, we are continuing to undertake major clinical trials for the benefit of future patients.”

Professor John Simes has been a founding member of AGITG and a member of the Board of Directors since 1996. He is the current group coordinator, and is a member of both the Scientific Advisory Committee, and the International Development Committee.

Professor Simes is the director and senior principal research fellow of the NHMRC Clinical Trials Centre, which he founded in 1988. He leads a team of almost 200 who collaborate with national and international clinical investigators and researchers to improve health practice and outcomes through better use of clinical trials research.

Professor Simes is also the director of the Sydney Catalyst Translational Cancer Research Centre. He co-leads over 400 cancer researchers and clinicians in NSW who undertake translational research that affects clinical policy and patient’s health. Additionally, he is a director of the Australian Clinical Trials Alliance (ACTA), formed in 2012, to promote effective and evidence based healthcare in Australia through investigator-initiated clinical trials. He is also a fellow of the Australian Academy of Health and Medical Sciences.

He has held leadership roles in several major clinical trials in cancer, cardiovascular disease, diabetes and neonatal medicine, which have led to gains in survival and better health outcomes through more effective care. He contributed to over 350 peer-reviewed  publications, with many having a significant impact on current knowledge and clinical practice. In 1986, he developed the Simes procedure, a multiple hypothesis statistical testing method that has underpinned the development of a number of other such methods.

He is currently Professor of Clinical Epidemiology at the University of Sydney, and a practising medical oncologist at the Royal Prince Alfred Hospital and Chris O’Brien Lifehouse.

This year, Professor Simes received the NSW Premier’s Award for Outstanding Cancer Research which recognises and celebrates excellence and innovation in cancer research.

He has also received the 2009 Distinguished Harvard Alum Award (Biostatistics), and the 2010 Medical Oncology Group of Australia Cancer Achievement Award for most outstanding cancer research.

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