2016 Pancreas Cancer Research Workshop

Pancreatic cancer workshop_website

AGITG – APC Pancreas Cancer Research Workshop

The AGITG and the Australasian Pancreas Club hosted the 4th Annual Pancreas Cancer Research Workshop on Tuesday 13 September, immediately preceding the AGITG 18th Annual Scientific Meeting.

The meeting was a resounding success with very good attendance across disciplines and robust, research-centred discussion.

We had two outstanding invited speakers, the first was Professor Edgar Ben-Josef, a distinguished radiation oncologist and researcher from the University of Pennsylvania who was able to elaborate on possible biomarkers for radiotherapy in pancreas cancer, and Dr Paul Timpson from The Garvan Institute who wowed the audience with his real-time studies of intravital imaging of pancreas cancer.

We were very pleased to have concepts presented from researchers based in Melbourne, Adelaide and Sydney. Concepts included further analysis of the APGI dataset in terms of long term survivors, as well as text mining to elucidate clinical syndromes associated with genomic aberrations.  We also heard from the Biogrid team who had a proposal for a translational registry.  A second-line clinical trial using panitumumab in KRASWT pancreas cancer was presented and also research into a diagnostic test for IPMN was workshopped.  Feedback from the presenters was that they were helped enormously by the input from the experts in the room.

Presentations included:

  • High Dose Radiotherapy for Unresectable Pancreatic Cancer
    Professor Edgar Ben-Josef
    Vice-Chair for Translational Research, Department of Radiation Oncology, University of Pennsylvania, Perelman Center for Advanced Medicine
  • Studying Metastatic Pancreas Cancer in Real Time
    Dr Paul Timpson
    Garvan Institute of Medical Research

Concepts presented:

Concept 1: Long Term Survivors in Pancreatic Cancer – Amber Johns et al.

Concept 2: Integrating clinical data with translational innovation through the PURPLE (Pancreatic cancer: Understanding Routine Practice and Lifting End results) Translational Registry – Dr Belinda Lee et al.

Concept 3: Panitumumab as second line therapy for advanced pancreatic ductal adenocarcinoma with wild‐type KRAS gene: A pilot activity study – Dr Daniel Croagh et al.

Concept 4: Clinical correlation of molecular subtypes of pancreatic cancer: presentation, response to treatment, patterns of progression – Dr Marie Christine Semira

Concept 5: Development of a Diagnostic Test for Intraductal Papillary Mucinous Neoplasm of Pancreas Based on Differential Expression of miRNA in Plasma – Dr Titus Kwok et al.

Concept 6: An exploratory text-mining analysis to identify clinical syndromes associated with somatic genomic aberrations in pancreatic cancer – Dr Frank Lin et al.

This open forum allows Australian investigators and researchers to share their ideas so that we can all appreciate the depth and breadth of research in this disease.  Our expert panel emphasized the need for collaboration, now more than ever as funding sources become scarce.

“It is evident from the concepts presented and the level of participation in the workshop that we have reached a critical mass in pancreatic cancer research,” said Dr Lorraine Chantrill, Co-Convenor Pancreatic Cancer Research Workshop. “As funding becomes more difficult to obtain, we are fortunate in Australia, to be in an excellent position to work together and leverage available opportunities. Now is the time to collaborate to improve treatment for patients with pancreatic cancer.”

 

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